Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Names and Identifiers

Name	Ethylmercurithiosalicylic acid
Synonyms	thimerosal merthiolate mercurothiolate sodium merthiolate Merthiolate sodium Ethylmercurithiosalicylic acid ethyl mercurithiosalicylic acid sodium ethylmercurithiosalicylate sodium 2-(ethylmercuriothio)benzoate Ethylmercury thiosalicylic acid sodium salt 2-(Ethylmercurio(II)thio)benzoic acid sodium mercury-[(o-carboxyphenyl)thio]ethyl sodium salt 2-(Ethylmercurio(II)thio)benzoic acid sodium salt 2-(ethylmercuriomercapto)benzoic acid sodium salt 2-(ethylmercuriomercapto)benzonic acid sodium salt ETHYLMERCURY THIOSALICYLICACID.NA-SALT RESEARCH GRADE thimerosal, usp grade sodium ethylmercurithiosalicylate sodium ethyl[2-(sulfanyl-kappaS)benzoato(2-)]mercurate(1-) Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate Thimerosal,2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate
CAS	54-64-8
EINECS	200-210-4
InChI	InChI=1/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2/rC9H10HgO2S.Na/c1-2-10-13-8-6-4-3-5-7(8)9(11)12;/h3-6H,2H2,1H3,(H,11,12);/q;+1/p-1
InChIKey	RTKIYNMVFMVABJ-UHFFFAOYSA-L

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Physico-chemical Properties

Molecular Formula	C9H9HgNaO2S
Molar Mass	404.81
Melting Point	234-237°C (dec.)(lit.)
Flash Point	250°C
Water Solubility	1 G/ML (20 ºC)
Solubility	methanol: 0.1g/mL, ≤ 10 TE CF
Appearance	Powder
Color	white to off-white
Merck	13,9389
BRN	8169555
PH	6.0～8.0 (10g/L, 25℃)
Storage Condition	Store at RT.
Stability	Stable. May degrade in sunlight. Incompatible with strong acids, strong bases, strong oxidizing agents, iodine, heavy metal salts.
Physical and Chemical Properties	Light cream-colored crystalline powder. LIGHT SENSITIVE.
Use	Used as a Disinfection antiseptic

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Risk and Safety

Risk Codes	R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S13 - Keep away from food, drink and animal foodstuffs. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A -
UN IDs	UN 2025 6.1/PG 3
WGK Germany	3
RTECS	OV8400000
FLUKA BRAND F CODES	8
TSCA	Yes
HS Code	29310095
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LD50 s.c. in rats: 98 mg/kg (Mason)

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Reference Information

Open Data Unverified Data

Ethylmercurithiosalicylic acid, also known as Thimerosal, has the chemical formula C9H9HgNaO2S and is a grayish-yellow powder. It is commonly used as a surgical disinfectant or vaccine preservative.

Properties:
Thimerosal has strong antibacterial and antifungal properties, effectively eliminating bacteria and fungi. It can also inhibit the growth of viruses to a certain extent. Therefore, it is widely used in the medical and health fields.

Uses:
Thimerosal is used in the preparation of surgical disinfectants for sterilizing instruments, operating rooms, and wounds. Additionally, it serves as a vaccine preservative, extending the shelf life of vaccines and ensuring they remain uncontaminated by bacteria and fungi during transportation and usage.

Production:
The synthesis of Thimerosal involves the reaction of thiosalicylic acid with mercuric chloride to obtain the final product.

Safety:
Thimerosal is an organic mercury compound and has a certain level of toxicity to humans and the environment. It is crucial to strictly adhere to safety procedures during its use, avoiding skin contact and inhalation of its vapors. Necessary protective measures need to be taken in medical and vaccine production to prevent harm to people and the environment. Proper disposal of Thimerosal after use is also essential to prevent environmental pollution.

Thimerosal	Thimerosal, also known as sodium thimerosal, ethyl mercury sodium thiosalicylate, is an organic mercury compound, in which the mercury content is 49.55%, It can be quickly decomposed in solution. Thimerosal metabolism or degradation products are ethyl mercury and thiosalicylate. Ethyl mercury is organic mercury degraded from dimethyl mercury. Thimerosal has strong antibacterial ability against gram-positive bacteria and gram-negative bacteria, and is a broad-spectrum bacteriostatic agent. At present, many toxoids, some blood products and some inactivated vaccines use thiomersal as a preservative, such as acellular DPT vaccine (DTaP), rabies vaccine, influenza vaccine, etc.
Structure and function	Thimerosal was originally patented by Kharasch Morris, a chemist at the University of Maryland in the United States, in 1927, and then Lilly and Company introduced it under the trade name "Merthiolate. Similar to other two-coordinated mercury compounds, the mercury element in thimerosal is also linearly distributed, and the bond angle of the S-Hg-C is 180 °. In addition, the presence of ortho carboxyl groups also increases the solubility of the compound in water. The preparation of thimerosal is not complicated. Using the affinity of sulfur and mercury, the white powdered thimerosal compound can be obtained by mixing 2-COOH-PhSNa and EtHgCl in equal proportions. At present, commonly used preservatives include thimerosal, chloroform, mercury nitrate benzene, carbolic acid, etc. Thimerosal is one of the most widely used biological preservatives at home and abroad. Since the 1930s, this chemical has been widely used in many biological products and medicines.
health hazards	the safety dispute of thimerosal began in the United States in 1999. according to the child immunization program in the United States at that time, the cumulative intake of mercury in the vaccinated vaccine may exceed that of the U.S. environmental protection agency (US Environmental Protection Agency, EPA) and the World Health Organization set safe limits for methylmercury intake (34 μg and 159 μg) for infants at 14 weeks of age respectively. The above-mentioned mercury exposure after vaccination with thiomersal-containing vaccine is actually based on the calculation of methylmercury threshold. However, thimerosal contains ethyl mercury, not methyl mercury. There is a big difference between ethyl mercury and methyl mercury, and the pharmacokinetics of the two are completely different. Pharmacokinetic studies of human infants (including premature and low birth weight infants) have found that the half-life of ethyl mercury is 3 to 7 days, and ethyl mercury can be effectively excreted in feces and will not accumulate in the blood for a long time. Therefore, its level will drop to the basic level 30 days after vaccination. In June 2012, the Global Advisory Committee on Vaccine Safety (GACVS) reviewed the recent research information on the safety of thimerosal. Based on the current evidence, GACVS considered that the current evidence strongly supports the safety of thimerosal as an inactivated vaccine preservative. At present, there is no evidence that thimerosal in vaccines is toxic to infants, children or adults. There is no reason to change the current immunization of thimerosal-containing vaccines on safety grounds.
biological activity	Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. has obtained a hazardous chemicals business license
use	used as antiseptic is an effective disinfectant, which can be used for disinfecting skin and mucous membranes, as well as antiseptic drugs. The preparation has tincture, cream.
category	pesticide
toxicity classification	highly toxic
acute toxicity	oral-rat LD50 75 mg/kg; Oral-mouse LD50: 81 mg/kg
flammability hazard characteristics	flammability, fire discharge mercury, nitrogen oxides, sulfur oxides, sodium oxide, pungent smoke
storage and transportation characteristics	warehouse is low temperature, ventilated and dry; Store separately from food raw materials
fire extinguishing agent	water, carbon dioxide, dry powder, sand
occupational standard	TWA 0.01 mg (mercury)/m3; STEL 0.03 mg (mercury)/m3
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 19:43:38

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate

Wuhan Xingzhongcheng Chemical limited company

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate

Ethylmercurithiosalicylic acid

CAS: 54-64-8

Molecular Formula: C9H9HgNaO2S

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Names and Identifiers

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Physico-chemical Properties

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Risk and Safety

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Reference Information

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Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate Request for Quotation

Ethylmercurithiosalicylic acid

CAS: 54-64-8

Molecular Formula: C9H9HgNaO2S

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Names and Identifiers

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Physico-chemical Properties

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Risk and Safety

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate - Reference Information

Open Data Unverified Data

Supplier List

Ethylmercurithiosalicylic Acid Sodium SaltSodium Ethylmercurithiosalicylate